文档介绍：A在子宫颈癌中的表达及临床意义
(作者:___________单位: ___________邮编: ___________)
作者:薄纯美作者单位:东营市人民医院妇产科东营市 257091
【摘要】目的研究抑癌基因p53和增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在子宫颈癌中的表达特点,并探讨其与病理分级的关系。方法 A的表达情况,并结合病理分级进行分析。结果①% (30 /35),% ( 2 /30) ,P = ;②P53蛋白阳性表达率与宫颈癌组织的病理学分级有关,P53在宫颈癌Ⅰ% (8 /14)明显低于Ⅱ% (13/15) 和Ⅲ% (6/6) ,P<;③A阳性表达率Ⅰ%明显低于Ⅱ%和Ⅲ%,P<。结论 p53 基因突变在宫颈鳞癌发生中起重要作用,A检测对于研究宫颈癌的发生、发展和评估子宫颈癌恶性程度具有重要意义。
【关键词】抑癌基因p53;PCNA;宫颈癌;免疫组织化学
【Abstract】 Objective To study the expression of p53 and proliferating cell nuclear antigen ( PCNA) proteins in primary cervical carcinomas and its
clinic The expression of p53 and PCNA proteins in 35 cases with cervical carcinomas and 30 cases of normal cervical tissues was detected by supersensitive ElivisionTM immunohistochemical ①p53 positive expression rate in cervical carcinomas % ( 30 /35) was significantly higher than that in normal cervixes % ( 2 /30),P= .②p53 expression is correlated with the differentiation state and pathologic positive expression rate of p53 in the cervical carcinomas of grades Ⅰ % (8 /14) was significantly lower than that in the cervical carcinomas of grades Ⅱ % (13 /15) and grades Ⅲ % (6 /6),P<.③The positive rate of PCNA in the cervical carcinoma of g