文档介绍：PCNA、Bcl2和Bax在喉癌组织中的表达及其意义
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作者:李正贤,刘庚勋,刘阳云,颜美荣
【摘要】目的 A、Bcl2和Bax的表达水平,A、Bcl发病机制中的作用。方法采用免疫组化Elivision法检测30例喉鳞状细胞癌、A、Bcl2和Bax的表达水平。结果 A、Bcl%(29/30),%(28/30)和60%(18/30),A、Bcl2和Bax的阳性表达率分别为60%(6/10),30%(3/10)和70%(7/10)。PCNA和Bcl2阳性表达两组间差异有统计学意义,,而Bax阳性表达两组间差异无统计学意义,。结论 A的高表达和Bcl2与Bax表达失衡有关,可能是细胞异常增生和凋亡失衡的共同结果
【关键词】 PCNA;Bcl2;Bax; 喉肿瘤; 鳞状细胞癌;凋亡;免疫组织化学
Abstract: Objective To study the expressions of PCNA, Bcl
2 and Bax in laryngeal squamous cell carcinoma () and their Immunohistochemical Elivision method was used to examine the expressions of PCNA, Bcl2 and Bax in 30 cases of and 10 cases of vocal cords atypical hyperplasia (VCAH).Results The positive rates of PCNA, Bcl2 and Bax were %, % and % in , and %, % and % in the VCAH, respectively. There were significant differences in the expressions of Bcl2 and PCNA between group and VCAH group (). There was no significant difference in the expression of Bax between the two groups ().Conclusion The overexpression of PCNA, as well as the unbalance between Bcl2 and Bax, may be a positive factor in the pathogenesis of . It is suggested that development may result from a cooperation of abnormal proliferation and unbalanced apoptosis.
Key words: proliferation cell nuclear antigen; Bcl2; Bax;