文档介绍：TC与GP方案治疗晚期肺鳞状细胞癌临床疗效观察对比
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【摘要】目的观察紫杉醇联合卡铂的TC方案与吉西他滨联合顺铂的GP方案治疗晚期肺鳞状细胞癌的疗效及毒副反应。方法回顾性分析75例晚期肺鳞状细胞癌患者,其中,TC组39例,GP组36例。结果 TC组有效率(CR + PR)%,,%,,两组间疗效比较差异无显著性()。主要不良反应为骨髓抑制、消化道反应、关节肌肉疼痛。结论两种联合化疗方案对晚期肺鳞状细胞癌疗效确切,两种方案疗效差异无显著性。
【关键词】肺鳞状细胞癌;联合化疗;紫杉醇;卡铂;吉西他滨;顺铂
【Abstract】 Objective To observe the therapeutic effects and toxic side effects of TC and GP regimen in the chemotherapy of patients with advanced squamous cell carcinoma of the Retrospective study was used to analyze the clinical data of 75 patients with advanced squamous cell carcinoma of the lung that treated with paclitaxel plus carboplatin or gemcitabine plus The overall reponse rate was % in TC group and % in GP group; The median TTP was and months was no significant difference in response rate and median TTP between the two groups
().The main toxic side effects were bone marrow depression,muscular soreness and gastrointestinal TC and GP regimens are both effective in advanced squamous cell carcinoma of the lung and have no significant difference.
【Key words】 squamous cell carcinoma of the lung; combined chemotherapy; paclitaxel; carboplatin;gemcitabine;cisplatin
肺癌发病率与死亡率为全球首位,其中非小细胞肺癌占肺癌75%~80%,大多数患者已处于中晚期阶段,以化疗为主的综合治疗在晚期非小细胞肺癌治疗中占有重要地