文档介绍：奥曲肽抑制人卵巢癌细胞增殖的研究
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作者:李炜虹,沈杨,张云霞,任慕兰
【摘要】目的:研究奥曲肽(OCT)对人卵巢癌细胞株SKOV3的影响。方法:建立人卵巢癌细胞株SKOV3裸鼠移植瘤模型,分成空白对照组、OCT组、顺铂组及OCT与顺铂联用组4组,分别予生理盐水、OCT、顺铂及两药联用处理,处死裸鼠后肿瘤标本采用免疫组织化学法检测血管内皮生长因子(VEGF)的表达。结果:各用药组瘤重、瘤体积、VEGF的表达均低于空白对照组()。结论:OCT能抑制体内人卵巢癌细胞株SKOV3生长。
【关键词】奥曲肽; 卵巢癌; 血管内皮生长因子
[Abstract] Objective: To study the effect of octreotide on the human ovarian cancer cell line SKOV3. Methods: Metastatic model simulating human ovarian cancer was established by implantation of the ovarian cancer cell line SKOV3 into nude mice. Animals were divided and submitted to different treatment groups:control group treated with physiological saline,octreotide group with octreotide,cDDP group with cDDP bination
group with octreotide and cDDP. The mice were killed and the tumor samples were isolated, vascular endothelial growth factor(VEGF) expression was examined by immunohistochemistry with VEGF antibody. Results: Tumor weights,volume and the expression of VEGF were less in the treated mice with drugs than that in the control mice(). Conclusion: Octreotide inhibits the growth of human ovarian cancer cell line SKOV3 in vivo.
[Key words] octreotide; ovarian cancer; vascular endothelial growth factor
生长抑素(somatostatin,SST)是一种环状多肽类激素,由Brazeau等[1]于1973年从羊下丘脑中分离提取。现在认为SST对许多疾病如肿瘤、炎症、糖尿病、癫痫、早老性痴呆、帕金森病、亨廷顿舞蹈病以及艾滋病的发生、发展和防治具有重要意义[2]。奥曲肽(SMS201995,OC