文档介绍：涤痰止咳口服液止咳、化痰、平喘的实验研究
作者:高凤辉张金妹刘建勋
【关键词】口服
【摘要】目的探讨涤痰止咳口服液对止咳、化痰、平喘的药理作用。方法利用化学佐剂复制动物模型,观察药物对这些模型的影响。结果涤痰止咳口服液对氨水及枸橼酸引发小鼠和幼年豚鼠咳嗽,可明显减少咳嗽次数,延长咳嗽潜伏期;明显增加小鼠、幼年大鼠的排痰量;对组织胺+乙酰胆碱混悬液诱发支气管哮喘可延长哮喘潜伏期时间、出现抽搐时间和发生跌倒时间。结论涤痰止咳口服液对止咳、化痰、平喘有明显的药理作用。
关键词涤痰止咳口服液动物模型止咳化痰平喘
【Abstract】 Objective To explore the effects of antitussive,elimating sputum and relieving asthma of Diˉtanzhike The animal model was set up by chemical adjuvant and the effects of Ditanzhike potion on animal model were The Diatanzhike potion had obvious antitussive effect on mice and guinea-pig couph induced by ammonia and citric acid,it can reduced the frequence of cough and lengthen the incubation period of cough;It had obvi
ous elimating sputum effect in mice and young rat,and can increase the volume of elimating sputum;The Ditanzhike potion can lengthen the incubation period of bronchial asthma induced by suspension of histamine and acetylcholine and delay the occurence of tic and The potion has significant effects of antitussive,eliˉmating sputum,and relieving asthma.
Key words ditanzhike potion animal model antitussive elimating sputum relieving asthma
涤痰止咳口服液临床主要用于小儿急、慢性支气管炎的治疗。本文就该药对止咳、化痰、平喘等动物模型进行了药理作用的实验研究。现报告如下。
1 实验材料
动物昆明小鼠,雌雄兼用,体重(±)g,由军事医学科学院实验动物中心提供,合格证号:〈医动字〉013023号。幼年豚鼠,体重(±)g,雌、雄各半,由中国医学科学院实验动物研究所提供。Wistar种雄性幼年大鼠,体重(±)