文档介绍：妊娠期甲亢治疗情况对子代预后的影响
作者:高洁锦,钱燕,朱雪洁,凌雅,池美珠
【摘要】目的:探讨孕妇妊娠合并甲状腺功能亢进症(甲亢)对子代预后的影响。方法:选取2004年1月至2007年12月在我院出生,母妊娠合并甲亢的新生儿52例,根据孕妇甲亢治疗情况分为甲亢治疗组(41例)与未治疗组(11例),对两组甲亢孕妇所分娩的婴儿甲状腺功能与生长发育进行随访、分析。结果:未治疗组中,%(4/11),%(5/11),%(6/11),%(2/11)。而治疗组中,%(1/41),%(4/41),未发生甲状腺功能减低症和小于胎龄儿。两组在婴儿甲状腺功能异常、早产及小于胎龄儿发生率上差异均有显著性(P <)。结论:母孕期甲亢未治疗者婴儿甲状腺功能异常、早产及小于胎龄儿发生率升高。合理治疗妊娠期甲亢对改善子代预后有积极意义。
【关键词】妊娠;甲状腺功能亢进症;甲状腺功能减低症;婴儿;新生儿
Abstract: Objective: To explore the effect of maternal hyperthyroidism during pregnancy on their offspring. Methods: The clinical data of 52 neonates of mothers with hyperthyroidism were to the maternal hyperthyroidism therapy,in
fants were divided into two groups:treated maternal hyperthyroidism group (41 infants) and un-treated group (11 infants). The thyroid function and growth in the two groups were analyzed. Results: The incidences of neonatal hyperthyroidism, neonatal hypothyroidism, premature infant and small for gestational age infant in un-treated group were %,%,% and %,respectivey,the inckidences of those in the treated group were %,0,% and 0,respectively. The difference was statistically significant(P <) in two groups of abnormal function of thyroid,premature infant and small for gestational age infant. Conclusion: In the infants of un-treated maternal hyperthyroidism,the rates of neonatal abnormal thyroid function, premature, and small for gestational age infant are maternal hyperthyroidism can improve the prognosis of offspring.
Key words: pregnancy;hyperthyroidism;hypothyroidism;infant;newborn
Graves病引起的甲状腺功能亢进症(甲亢)好发于育龄妇女,%~%[1],其生育后代发生早产、宫内生长迟缓、甲状腺功能异常的危险性明显增加,如未能及时发现和干预,轻者引起智能发育障碍和生长迟缓,重者可能引起死亡[2]。目前国内有关妊娠期甲亢对子代的影响的研究报道较少。现将我院52例妊娠期甲亢母亲婴儿的转归情况报告如下。
1 资料和方法
资料来源和分组
选取2004年1月至2007年12月其母妊娠期甲亢52例为研究对象,根据妊娠期治疗情况,分为甲亢治疗组与甲亢未治疗组,甲亢治疗组41例,甲亢未治疗组11例。甲亢治疗组是指孕前或孕期发现甲亢,经治疗、定期随访,维持甲状腺功能在正常范围或略高