文档介绍：Exploration of RNA Editing and Design of Robust ic Algorithms
Chien-Feng Huang Luis M. Rocha
Modeling, Algorithms and Informatics Group (CCS-3) Modeling, Algorithms and Informatics Group (CCS-3)
Computer putational Sciences puter putational Sciences Division
Los Alamos National Laboratory, MS B256 Los Alamos National Laboratory, MS B256
Los Alamos, NM 87545, USA Los Alamos, NM 87545, USA
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Abstract -- This paper presents putational single uridine can change dramatically the amino acid
methodology using ic Algorithms (GA) for sequence obtained; in this case, a termination codon is
exploring the nature of RNA editing. These models are introduced. It is important to retain that a mRNA molecule
constructed using several ic editing can be more or less edited according to the concentrations
characteristics that are gleaned from the RNA editing of the editing operators it encounters. Thus, several
system as observed in anisms. We have different proteins coded by the same gene may coexist in
expanded the traditional ic Algorithm with anism or even a cell, if all (or some) of the mRNA’s
artificial editing mechanisms as proposed by (Rocha, obtained from the same gene, but edited differently, are
1997). The incorporation of editing mechanisms meaningful to the translation mechanism.
provides a means for artificial ag