文档介绍：Case0810257,1851508男,73岁,主因“咳嗽2月,伴胸闷气喘20天”入院。(左肺上叶开口处)癌细胞CK(+),CK-L(+),CK-H(-),CK7(-),NapsinA(-),TTF-1(+),Syn(++),CgA(+),CD56(++),Ki-67(70%+),结合HE切片,本例应为小细胞癌。(SCLC):non–smallcelllungcarcinoma(non-SCLC)ountfor13%–15%monprimarypulmonaryneuroendocrineneoplasmCigarettesmokingisresponsibleforapproximately95%ofcases,andofallthehistologicsubtypesoflungcancer,SCLChasthestrongestassociationwithcigarettesmokingClassificationofPulmonaryNeuroendocrineNeoplasms(VALSG)Low-grade:typicalcarcinoidtumor(典型类癌)intermediate-grade:atypicalcarcinoids(非典型类癌)high-grade:umorandSCLCEpidemiologicandClinicalFeaturesSCLCtypicallyaffectspatientsbetweentheagesof60and70yearsmen:women=:1commonsigns:cough,chestpain,hemoptysis(咯血),anddyspneaspecificsymptoms上腔静脉受压综合征食道及纵隔的侵犯副癌综合症:抗利尿激素异常分泌综合征(SIADH),Cushing综合症,重症肌无力,脑脊髓炎,边缘叶脑炎神经内分泌症状比肿瘤的发现早2年HistologicandGrossPathologicFeaturesAtlightmicroscopy,SCLCischaracterizedbysmallblueround,oval,orspindle-shapedcellswithscantcytoplasm,ill-definedborders,finelygranularnuclearchromatin(核染色质颗粒),umors,