文档介绍：肺癌LUNG CANCER彭小波2012-12-3流行病学?肺癌发病率男性肿瘤占第一位,女性为第二位,肺癌死亡率男女均占癌症死亡首位。?发病率和死亡率都有明显增高趋势?2005年7月第十一届世界肺癌大会报道:肺癌发病率占世界所有癌症的12%,肺癌死亡约占所有癌症死亡的1/3。*Incidence per 100,000 Eastern EuropeEuropeJapanJapanAustraliaAustraliaNew ZealandNew ZealandChinaChinaNorthern Northern AfricaAfricaSouthern Southern AfricaAfricaCentral Central AmericaAmericaWesternWestern Europe Europe NorthNorthAmericaAmericaTemperate Temperate South AmericaSouth America LUNG CANCER LUNG CANCERWorldwide incidenceWorldwide incidence**??男性男性>>女性女性男男::女女33~~5:15:17%12%21%13%10%8%10%20%14%Eastern Eastern EuropeEuropeJapanJapanAustraliaAustraliaNew ZealandNew ZealandChinaChinaMiddle East/Middle East/Northern AfricaNorthern AfricaSub-Saharan Sub-Saharan AfricaAfricaLatin America/Latin America/CaribbeanCaribbeanNorthwesternNorthwestern Europe Europe NorthNorthAmericaAmericaLUNG CANCERLUNG CANCER5-year survival rates5-year survival rates2005 Estimated US Cancer Deaths*ONS=Other nervous : American Cancer Society, ,280Women275,000?27%Lung and bronchus?15%Breast?10%Colon and rectum? 6%Ovary? 6%Pancreas? 4%Leukemia? 3%Non-Hodgkin lymphoma? 3%Uterine corpus? 2%Multiple myeloma? 2%Brain/ONS?22% All other sitesLung and bronchus31%Prostate10%Colon and rectum10%Pancreas5%Leukemia4%Esophagus4%Liver and intrahepatic3%bile ductNon-Hodgkin Lymphoma 3%Urinary bladder3%Kidney3%All other sites 24%病因1、吸烟★吸烟是导致肺癌的首要危险因素20世纪50-60年代★吸烟者比不吸烟者肺癌的发病率高10-13倍★吸烟过程中可产生3500种不同的化学物质,其中至少有43种是致癌物质, 苯并芘为主要的致癌物质★吸烟与肺癌危险度的关系与烟草的种类、开始吸烟的年龄、吸烟的年限、吸烟量有关