男性型脱发患者头皮雄激素受体表达探究.doc

文档介绍：:..男性型脱发患者头皮雄激素受体表达探究[摘要]目的:了解男性型脱发患者头皮雄激素受体(androgenreceptor,AR)表达情况。方法:对来自10例男性AGA患者和3例正常人的头皮,采用免疫组化的方法检测男性型脱发患者头皮不同区域AR的表达。结果:患者不同部位总的AR表达比较,均有明显差异(),但均明显强于正常对照组('结论:男性型脱发患者不同区域头皮AR的表达是有区别的;毛囊隆突部和漏斗部,交界区及脱发区AR表达明显增强,可能是男性型脱发的重要原因之—。[关键词]男性型脱发;雄激素受体[中图分类号][文献标识码]A[文章编■^]1008-6455(2012)05-0778-04AndrogenreceptorexpressioninmalepatternbaldnesspatientsHUANGTao1,2,WANMiao-jian1,DONGJia-hui1,3,FENGZhi-ying4,XIEXiao-yuan1,LIYing1,5丄AlWei1,JIBin6(,The3rdAffiliatedHospitalofSunYat-SanUniversity,Guangzhou510630,Guangdong,China; ofDermatology,TheFirstAffiliatedHospitalofGuangxiUniversityofChineseMedicine;;,The3rdAffiliatedHospitalofSunYat-SanUniversity;,GuangzhouTheEighthMunicipalPeople')Abstract:ObjectiveToinvestigateAR(androgenreceptor)expressioninmalepatternbaldness・MethodsObtainfolliclesfromdifferentscalpareas(occipitalareaofnon・hairloss,hairlosstransitionandhairlosszonearea)of10maleAGA(icalopecia)patientsand3normalscalp・,ipitalandthenormalcontrolgroup()ipitalarea,hairlossareaandthetransitionalarea,paredtonormalcontrolgrou