文档介绍：:..蜀梅颗粒治疗过敏性鼻炎的临床疗效观察【摘要】丨1的:观察绮梅颗粒治疗过敏性鼻炎(allergicrhinitis,AR)的临床疗效。方法:过敏性鼻炎患者30例(观察组),采川蜀梅颗粒治疗,对照组37例,服用鼻炎丿隶,比较两组治疗前、后的主要症状、体征及血淸中相关免疫分子。结果:蜀梅颗粒治疗后喷嚏、流涕的症状及生命体征明显改善(P<),鼻塞、鼻痒的症状亦有所减轻(P〈)。治疗后患者血淸IgE、IL-13值显著降低(P〈),TNF・ci、IFN-Y值明显升高(P(),与对照组接近。结论:蜀梅颗粒的有效成分对于改善机体免疫功能具有明显作用,其下调患者血清IgEJL-13和调节ThlfTh2反应平衡可能是其主要作用机制之一。【关键词】过敏性鼻炎;蜀梅颗粒;免疫球蛋口E;肿瘤坏死因子a;干扰素[ABSTRACT]Objective::Thirtypatientswithallergicrhinitis(observationgroup)weretreatedwithShumeigranules,thecontrolgroup(37cases),:Theobservationgroupshowedsignificantimprovementsinbothphysicalsignsandsymptomsincludingsneezing,runnynose(P(,obstructinganditchingnosewerealsorelieved(P().Afterthetreatment,serumIgEandIL-13oftheobservationgroupweresignificantlyreduced(P〈);whileTNF-&alphn;andIFN・&gamma;levelsweresignificantlyincreased(P〈).Conclusions:ShumeigranulescandecreaseserumIgEandIL-13levels,andregulatetheThl/Th2balance,whichmightbethemainmechanismforitsfunctionofimprovingpatients&prime;immunity.[KEYWORDS]Allergicrhinitis;Shumeigranules;IgE;TNF-&alpha;;IFN-&gamma;过皈性鼻炎(allergicrhinitis,AR)乂称变态反应性鼻炎,中IK名”鼻飙“,是耳鼻咽喉科一种难治的常见病和多发病,其典型临床表现为鼻痒、阵发性喷嚏连续性发作、大量水样鼻涕和鼻塞[1,2]。过頌性鼻炎的发病机制为发牛在昴黏膜的