文档介绍：原发性干燥综合症患者血清IL                     作者:袁双龙,蒋莉,张晓莉,李舒帆,段宏梅,王晓非【关键词】 原发性干燥综合症;,甲状腺功能减退症;白细胞介素 SerumIL21levelinpatientswithprimarySjgren’ssyndromeandclinicalsignificanceofIL21 [Abstract] AIM:ToinvestigatetherelationbetweenthechangeofserumIL21levelandotherlaboratoryindexesbydetectingserumIL21levelfrompatientswithprimarySjgren’ssyndrome(pSS)andexploretheroleofIL21inpSS. METHODS:ordingto2002revisedinternationalclassificationcriteriaforpSSand30healthypersonsweredetectedbyenzymelinkedimmunosorbentassay(ELISA),FT3,FT4,TSH,TgAb,,WestergrenandautomaticgelmethoddetectedantSSAandantSSBantibody,:ThelevelofserumIL21inpatientswithpSS(1051±335)ng/Lwasobviouslyhigherthanthatinhealthycontrol(466±90ng/L),(P<).ThelevelsofserumIL21intheselfantibodypositivegroup,parotidglandswellingpaingroup,rashgroupandincorporatinghypothyroidismgroupwerehigherthanthoseintheirnegativecontrolgroups,andthereweresignificantdifferences(P<).Inaddition,ThelevelofserumIL21levelinpSSpatientsshowedpositivecorrelationwithγglobulin(r=,P<)andESRlevel(r=,P<).CONCLUSION:TheevidentincreaseofserumIL21levelinpSSpatientshaspositivecorrelationwiththelevelsofγglobulinandESR,whichsugge