瘦素与体外循环胰岛素抵抗关系的研究.doc

文档介绍：瘦素与体外循环胰岛素抵抗关系的研究作者:张拥军,胡知朋,聂荣华*,陈家军,詹波涛,杨俊波,张增旺作者单位:(华中科技大学同济医学院附属襄樊医院心胸外科,湖北襄樊441021) 【摘要】目的:探讨血瘦素浓度与体外循环(CPB)手术患者胰岛素抵抗的关系。方法:中低温体外循环手术22例,于麻醉诱导前、体外循环开始30min、开放主动脉、体外循环开始后6、12、18、24h抽取颈内静脉或体外循环血液,检测血糖、血清胰岛素浓度、血清瘦素浓度,计算各时间点胰岛素抵抗指数(HOMAIR)并分析它与血清瘦素浓度的关系。结果:CPB过程中、CPB术后胰岛素抵抗指数均降低;血清瘦素浓度在CPB过程中明显降低,CPB术后逐渐恢复;体外循环过程中血清瘦素浓度与胰岛素抵抗指数无明显相关性,CPB术后血清瘦素浓度与胰岛素抵抗系数呈正相关,P<。结论:CPB术后血瘦素浓度改变与体外循环胰岛素抵抗正相关,CPB术中胰岛素抵抗可能与血瘦素浓度的改变没有关系。【关键词】体外循环;瘦素;胰岛素抵抗 StudyontheRelationshipBetweenLeptinandInsulinResistanceinPatientsUndergoingCardiopulmonaryBypassZHANGYongjun,HUZhipeng,NIERonghua*,CHENJiajun,ZHANBotao,YANGJunbo,ZHANGZengwang(DepartmentofCardiothoracicSurgery,XiangfanHospitalAffiliatedtoTongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Xiangfan,Hubei441021,China) Abstract:ObjectiveToexploretherelationshipbetweenleptinandinsulinresistanceinpatientsundergoingcardiopulmonarybypass(CPB).MethodsTwentytwopatientswereperformedCPBundermediumhypothermia,andbloodsampleswereobtainedatfollowingintervals:beforeanesthesiainduction,30minutesafterCPB,declampingofaorta,6hafterCPB,12hafterCPB,18hafterCPB,,bloodglucose,seruminsulinweredetermined,IRweredecreasedbothduringandafterCPB,theconcentrationofserumleptinwassignificantlyde