文档介绍：页眉...页脚缺血后处理对后肢挤压伤兔全身炎症反应的抑制作者:丁俊涛,张连阳作者单位:(第三军医大学第三附属医院野战外科研究所,全军战创伤中心,创伤、烧伤与复合伤国家重点实验室,重庆400042)【摘要】目的探讨两种缺血后处理方式(IP)对后肢挤压伤兔全身炎症反应的抑制作用。方法建立兔后肢挤压伤模型,分别采用交替夹闭开放挤压伤侧髂总动静脉及交替捆绑松弛挤压伤肢体近端两种IP方式处理后肢挤压伤兔,检测处理前、处理后2、6、12、24小时后血浆白介素6(IL6)、白介素10(IL10)及肿瘤坏死因子Α(TNFΑ)水平,比较两种处理方式组及对照组上述指标的变化。结果IP组在上述处理后4个时相点IL6及TNFΑ水平均低于对照组(P<),处理后2、6、12小时血浆IL10水平高于对照组(P<);但两种IP模式组间无差别(P>)。结论IP对后肢挤压伤早期兔全身炎症反应有抑制作用。【关键词】挤压伤;肢体;缺血;全身炎症反应综合征AInhibitionofischemicpostconditioningtoSIRSonthemodelofhindlimbcrushinjuryinrabbitsDINGJuntao,ZHANGLianyang(CenterofWarWoundandTraumaofPLA,StateKeyLaboratoryofTrauma,binedInjury,InstituteofSurgeryResearch,DapingHospital,ThirdMilitary页眉...页脚MedicalUniversity,Chongqing400042,China)Abstract:ObjectiveTodiscusstheinhibitionofischemicpostconditioningtosystemicinflammatoryresponsesyndrome(SIRS),,andthenperformedexaminationsonserumlevelofinterleukin6(IL6),interleukin10(IL10)andtumornecrosisfactorΑ(TNFΑ)at2,6,,6,12and24hoursafterinjuryintwogroupsofischemicpostconditioningwerehigher,andasignificantincreaseinserumlevelofIL10at2,paredwiththecontrolgroup(P<).Buttherewasnodifferencebetweenthetwog