文档介绍：自身免疫性感音神经性聋的内耳代谢与电生理研究谭长强1 曹银成1 胡平2 童素琴3 何学勤1 摘要为探讨自身免疫性感音神经性聋(ASHL)的内耳病理生理学机制,采用听觉电生理技术和酶组织化学方法,观察ASHL模型动物的内耳生理功能与组织内主要酶活性的变化。结果示:听神经复合动作电位和耳蜗微音器电位阈值明显升高,内淋巴电位(包括负相)幅值均有不同程度的降低,并与血管纹和内淋巴囊局部组织内Na+-K+-ATP酶和琥珀酸脱氢酶活性改变之间有相关性。表明自身免疫性内耳损伤,进而造成组织内相关酶代谢异常,是听觉功能障碍的病理基础。关键词自身免疫病感音神经性聋酶组织化学内淋巴电位TheexperimentalresearchofinnerearmetabolismandelectricalphysiologyofautoimmunesensorineuralhearinglossTanChangqiang CaoYincheng HuPin etal(DepartmentofOtorhinolaryngology,AffiliatedHospitalofNanjingRailwayMedicalCollege,Nanjing210009) Abstract Inquireintothemechanismofinnerearpathologicalphysiologyinautoimmunesensorineuralhearingloss(ASHL).Withtheauditoryelectric-physiologicaltechniquesandenzyme-histochemicalmethod,,poundactivepotential(CAP)andcochlearmicrophonicpotential(CM)heighteningevidently,showedthattheamplitudeofendolymphaticpotential(EP)(include-EP)bringdowninvariousdegress,whichwasrelatedtothechangeoftheactiveofNa+-K+-,whichfollowingautoimmuneinflammationdamage,isthepathologicalfoundationofhearingdysfunction. Keywords Autoimmunedisease Sensorineuralhearingloss Enzyme-histochemistry Endolymphaticpotential 自身免疫性感音神经性聋(autoimmunesensorineuralhearingloss,ASHL)作为目前少数可以有效治疗的感音神经性聋(sensorineuralhearingloss,SNHL)之一,对其研究工作已