文档介绍：:..-51915776QQ:767669939百家期刊包发快板f咨深机构值得信血%血浆置换对慢性乙型重型肝炎患者血清细胞因子影响的研究[摘要]目的:研究血浆置换对慢性乙型重型肝炎患者血清口介素T2(II-12)、白介素-18(IL-18)和白介素-10(IL-10)的影响。方法:40例慢性乙型重型肝炎患者,分别在血浆置换治疗前后检测血清IL-12、IL-18和IL-10的水平,同时检测肝功能、凝血酶原活动度(PTA),并与健康对照组比较。结果:慢性乙型重型肝炎患者治疗前血清IL-12>IL-18水平明显升高,IL-10水平下降(均P<);血浆置换治疗后血清IL-12、IL-18水平较前显著下降,IL-10水平较前显著升高(均P<)。血浆置换治疗对肝功能的恢复及PTA的升高有明显疗效。结论:血浆置换可降低慢性乙型重型肝炎患者血清IL--18的水平,提升IL-10的水平,保护肝细胞,促进病情的恢复。[关键词]血浆置换;慢性乙型重型肝炎;白细胞介素StudyofplasmaexchangeonserumcytokinesinpatientswithchronicseverehepatitisBDINGNingling,ZHUXiang,WANGYongping(DepartmentofInfectiousDisease,theFifthPeoplezsHospitalofSuzhouCity,JiangsuProvince,Suzhou215007,China)[Abstract]Objective:TostudythechangeofserumILT2、IL-18andIL-10inpatientswithchronicseverehepatitis(CSH)Btreatedbyplasmaexchange(PE)・Methods:40patientsweretestedthelevelofILT2,IL-18,IL-10andliverfunctionandPTAbeforeandafterPE,paredwiththoseofhealthycontrolgroup・Results:BeforePE,thelevelofIL-12,职称论文发表专家-51915776QQ:767669939百家期刊包发快板(咨深机构值得信血%IL-18inpatientswithCSHBwentupobviously,whilethelevelofIL-10wentdownobviously(allP〈0・paredwiththehealthypeople・AfterPE,thelevelofIL-12,IL-18wentclown,whi1ethelevelofIL-10wentup(allP〈).PEtreatmenthadobviouseffectintherecoveryofliverfunctionandtheincreaseofPTA・Conclusion:PEcanreducethelevelofIL~12,IL-18andascendthe1evelofIL-10int