文档介绍：辛伐他汀、阿托伐他汀对脑缺血再灌注大鼠血清MDA、SOD的影响        [11-04-0414:36:00]    编辑:studa20                    作者:袁胜山余昌胤,张骏,蔡志友,陈然  【摘要】 目的观察阿托伐他汀、辛伐他汀对大鼠脑缺血再灌注血清超氧化物歧化酶(SOD)和丙二醛(MDA)浓度的影响,探讨他汀类药物对脑缺血再灌注后自由基的清除作用。方法将36只Wistar大鼠随机分为假手术组,缺血再灌注组,阿托伐他汀预处理高、低剂量组,辛伐他汀预处理高、低剂量组(每组6只)。高、低剂量组分别予6mg/(kg·d)/(kg·d)阿托伐他汀/辛伐他汀灌胃,连续给药7天。用线栓法制备大脑中动脉缺血再灌注模型,缺血2h,再灌注22h。用比色法检测外周血中MDA、SOD的浓度。HE染色观察大鼠脑组织的病理学改变。结果辛伐他汀、阿托伐他汀预处理各组外周血SOD浓度较缺血再灌注组显著升高、MDA浓度显著降低(P<<)。各预处理组之间差异无显著性(P>)。结论辛伐他汀、阿托伐他汀预处理能提高大鼠脑缺血再灌注后外周血SOD浓度、降低MDA浓度。【关键词】 脑缺血;再灌注损伤;辛伐他汀;阿托伐他汀;超氧化物歧化酶;丙二醛SimvastatinandatorvastatininfluenceonserumMDA,SODinratswithfocalcerebralischemia-reperfusioninjury YUANSheng-shan1,YUChang-yin2,ZhangJun2,CAIZhi-you2,CHENRan3 (,AffiliatedHospitalofYoujiangMedicalCollegeforNationalities, Baise,Guangxi533000,China;,AffiliatedHospitalofZunyiMedical College,Zunyi,Guizhou563003,China;,LiuanPeople's Hospital,Liuan,Anhui237005,China) Abstract:ObjectiveToobservetheinfluencesofsimvastatin(Sim)andatorvastatin(Ator)onconcentrationofserummalondialdehyde(MDA),superoxidedismutase(SOD):shamischemicgroup(Shamgroup),ischemia-reperfusiongroup(IRgroup),andSimandAtorpreconditioninginhighandlowdosegroups,6ratsi