文档介绍：碟脉灵注射液对急性血瘀模型大鼠血液流变学的影响【摘要】目的探讨碟脉灵注射液对急性血瘀模型大鼠血液流变学的影响。方法采用大鼠皮下注射0(1,肾上腺素0(2ml加冰水中浸泡5min复制急性血瘀模型,观察碟脉灵注射液(DMLI)对急性血瘀模型大鼠血液流变学的影响。结果DMLI5、10g生药,(kg?d)可使急性血瘀模型大鼠全血黏度、血浆黏度、血浆纤维蛋白原浓度、红细胞沉降率、红细胞压积、红细胞电泳时间、红细胞聚集指数及红细胞刚性指数均明显降低。结论DMLI对急性血瘀模型大鼠血液流变学的异常变化有明显改善作用,这对于防止急性心肌梗死时的高黏状态以及动脉硬化的发展均有益处。【关键词】碟脉灵注射液;急性血瘀模型;血液流变学;大鼠EffectesofDiemailinginjection(DMLI)onhemorheologyinratsofacutebloodstasismodelXIAOHan,YUXiao-feng,QUShao-chun,etal(Dept(ofPharmacology,PharmacyCollege,JilinUniversity,Changchun130021,China【Abstract】ObjectiveToobservetheeffectofDMLIonhemorheologyinratofacutebloodstasismadel(MethodsAcutebloodstasismodelwaspreparedbyhypeadrenalineanddippinginicewaterinratsandeffectsofDMLIonhemorheologyinratsofacutebloodstasismodelwereobserved(ResultsDMLI(5and10g,kg?d)couldreducesignificantlywholebloodviscosity,plasmaviscosity,concentrationonplasmafibrinogen,erythrocytesedimentation,hematocrit,erythrocyteelectrophoresistime,erythrocyteaggregateindexanderythrocyterigidindex(ConclusionItisindicatedthatDMLIcanimprovesignificantlyabnormalchangeofhemorheologyinratsofacutebloodstasismodel,whichisbenefittopreventhighviscosityinacutemyocardialinfarctionanddevelopmentofarteriosclerosis(【Keywords】Diemailinginjection;Acutebloodstasis,model;Hemorheology;Rat碟脉灵注射液(diemailinginjection,DMLI)系由菊科植物抱茎苦卖菜IxerisSonchifolia(Bgg)Hance全草制备的纯中药制剂,有效成分为腺苷及黄酮类物质,具有抗血小板聚集、抑制血栓形成、促进血栓溶解、扩张血管及镇痛和镇静等作用。临床主要用于治疗脑血栓、脑梗死、冠心