Krupel样转录因子家族在免疫细胞中的作用.doc

文档介绍：
Krupel 样转录因子家族在免疫细胞中的
作用#
张伟,索珊珊,汪洌**
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(浙江大学医学部免疫学研究所,杭州 310058)
摘要:KLF(Kruppel-like factors)是锌指蛋白超家族的一个亚家族。目前在哺乳动物中发现
的该家族成员已有 17 个。通过调控基因转录,KLF 家族成员参与细胞生长、发育、分化和
激活、凋亡等多个方面。特别是在与免疫细胞相关的各种反应中,越来越多的研究证实,
KLF 家族的许多成员是许多重要生理活动的下游激活靶点和信号传导通路,包括 T 细胞迁
移、Treg 细胞的分化或功能抑制、单核巨噬细胞的激活或更新以及 B 记忆细胞的成熟化和
激活等。本文综述了 KLF 家族的结构特点,并特别阐述了与免疫细胞相关的 8 个 KLF 家族
成员在 T 细胞、单核巨噬细胞、粒细胞以及 B 细胞分化发育中的作用。
关键词:KLFs;T 细胞;巨噬细胞;B 细胞;转录调控
The role of Kruppel-like factors in immune system
ZHANG Wei, SUO Shanshan, WANG Lie
(Institute of Immunology, Zhejiang University School of Medical, HangZhou 310058)
Abstract: Kruppel-like transcription factors (KLF) family is a subgroup in the Zinc finger protein
super family. To date, there are 17 members of the mammalian KLF family. The KLF family
participates in diverse aspects of cellular growth, development, activation, differentiation and
apoptosis. Nowadays more and more studies indicated that Kruppel-like factors (KLFs) may be
key transacting factors that involved in leukocyte biology, including migration of T cells,
differentiation and function of regulatory T cells, activation or renewal of
mononuclear-macrophage, and maturation or activation of B cells. In this article, we reviewed the
structural features of KLF family and especially the function of several KLFs that involved in
leukocyte biology.
Keywords: KLF