文档介绍：
The role of Fascin-1 and E-cadherin expression in laryngeal
squamous cell carcinoma#
ZOU Jian, YANG Hui, CHEN Fei, LI Wen, WANG Lihong, LIU Shixi*
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(Department of Otolaryngology, West China Hospital of Sichuan University, ChengDu 610041)
Abstract: Fascin-1 and E-cadherin which are related with cell motility and cell adhesiveness are
important factors in the progression and metastasis of cancers. The objective of this study was to
explore the association of Fascin-1 and E-cadherin expression level with clinical characteristics and
prognosis of patients with laryngeal squamous cell carcinoma. In our study, tumor tissue samples from
150 patients with laryngeal squamous cell carcinoma were determined for Fascin-1 and E-cadherin
expression by immunohistochemistry. The statistical analysis was performed to evaluate the association
of Fascin-1 and E-cadherin expression with clinical characteristics and patient's prognosis. As a result,
Fascin-1 expression was an independent predictive factors for recurrence in patients with laryngeal
squamous cell carcinoma (P=) and independently related to disease-free survival(P=).
Although E-cadherin expression status was not the independent predictive factors for recurrence
(P=) or disease-free survival (P=), the subgroup with Fascin-1 high expression/E-cadherin
low expression has the poorest prognosis (P=) using subgroup analysis. In conclusion, Fascin-1
expression could be a potential prognostic predictor for patients with laryngeal squamous cell
carcinoma. Simultaneous analysis of Fascin-1 and E-cadherin expression could be more effective to
evaluate the prognosis of patients with laryngeal squamous cell carcinoma.
Keywords: Fascin-1; E-cadherin; Laryngeal squamous cell carcinoma; Immunohistochemistry;
Recurrence
0 Introduction
Laryngeal cancer is the mon head and neck malignancy in the worldwide, with a
tendency towards an increasingly occurrence