文档介绍:Ne神经化学DOI----:-,,KeylaPerez,IreneVolitakes,otosto,JeffreyKwok,NicoleCritch,NikkiSherratt,MikhalinaCortes,VarshaLal,,KazumaMurakami,RobertoCappai,,*,otosto,妮可不久后,尼基中,杰弗里·郭Mikhalina议会,VarshaLal,科林·l·大师Kazuma村上,,凯文·j·Barnham*Alzheimer_sdisease(AD)isanage-,themainconstituentofwhichistheamyloidb-peptide(Ab),posedofhyperphosphorylatedtauprotein.[1]CurrentevidencesuggeststhattheaggregationofAbsdrivesthediseaseprocess,asvariousformsofaggregatedAbhavebeenshowntobetoxic,[2]resultinginthedevelopmentofavarietyoftherapeuticstrategiesthattargetAb.[3–6]Todate,entralandC-terminalregionsofAb,whichareingeneralconjugatedpolyaromaticmoleculesthatareveryhydrophobic.[7]Herein,(6,13,and14)neartheNterminus,andtheinteractionofthissitewithzincandcoppermodulatestheaggregationandtoxicityofAb.[8,9]Wehavepreviouslytakenadvantageofthemetal-plexesof1,10-phenanthrolineligandstargetthissite,thusinhibitingAbaggregationinvi