文档介绍：2型糖尿病大鼠早期肾损害探究[摘要]目的:探讨在2型糖尿病(NIDDM)大鼠早期肾损害过程中血浆中降钙素基因相关肽(CGRP)、内皮素(ET)含量的变化规律,为早期防治糖尿病肾病(DN)提供理论依据。方法:采用链腺菌素(STZ)造成大鼠糖耐量异常,然后喂以高糖、高脂肪饲料10周,造成2型糖尿病模型,分别测成型前4、2周、成型时、成型后2、4周血浆中CGRP、内皮素(ET)含量的变化。结果:成型前4周血浆CGRP、ET无明显改变;而成型前2周、成型时、成型后2、4周血浆中CGRP进行性下降,同时血浆中ET含量明显增加。结论:CGRP、ET相互作用共同参与DM肾损害的发生、发展。动态观察血浆CGRP、ET的变化,对于早期发现DN及分析病情有重要意义。[关键词]降钙素基因相关肽;内皮素;糖尿病;糖尿病肾损害[中图分类号][文献标识码]A[文章编号]1673-7210(2009)07(a)-025-02Studyofearlykidneydamageinratswithnon-insulindependentdiabetesmellitus(NIDDM)LICu订ingl,LIJinling2,ZHANGWen3(GuangzhouWomenandChildren'sMedicalCenter,Guangzhou510120,China)[Abstract]Objective:TostudythechangesoflevelsofCGRPandETinserumofearlykidneydamageinratswithnon-insulindependentdiabetesmellitus(NIDDM).:RatsweregivedSTZanddevelopedimpainedglucosetoleranee,,NIDDMmodelswereformed・:TheconcentrationofCGRPandETdidnotobviouslyalterinserumatthe4thweekbeforethemodelswereformed,whiletheseindicatorsincreasinglydeclinedatthe2ndweekbefore,whenthemodelswereformedandatthe2ndand4thweeksaftermodelswereformed;meanwhile,:TheinteractionsofCGRP,