文档介绍：TP及CAP化疗方案治疗晚期卵巢癌的比较【关键词】CAP化疗【摘要】H的探讨进口紫杉醇与顺钳联合化疗方案(TP)治疗晚期卵巢癌的疗效及毒性作用。方法XJ1996年1月〜2003年6月采用TP化疗方案治疗的晚期卵巢癌患者进行冋顾性分析,并与环磷酰***(C)、阿霉素(A)及顺钳(P)联合化疗方案(CAP)进行比较。TP组20例,CAP组36例。结果TP组有•%,CAP—%,两组间差异有非常显著性()。TP组的不良反应在骨髄抑制、消化道症状、川:肾损害方而小于CAP组,在肌肉痛、手足麻木方而大于CAP组,两组间差异有显著性()。而口腔炎、脱发、发热、面部潮红两组间差异无显著性(P>)o结论TP作为治疗晚期卵巢癌一线用药疗效高于CAP,|(ij且毒副作用小,推荐作为治疗晚期卵巢癌的一线方案。binationtherapywithTPandCAPintreatmentofadvancedovariancarcinomaLiuJunbao,LengWeichun,,China-JapanUnionHospitalofJilinUniversity,Changchun130031.【Abstract]binedwithplatinum(TP)inthetreat--binationofcyclophosphamide,adri-amycinandplatinum(CAP).20patientsinTPgroup,-tiverateinTPgroupwas75・0%,%,therewereobviousdifferencesbetweentwogroups(P<).Thereweremyelosuppression,nausea,vomitinganddysfunctionofliverandkidneyintheside--effectsofTPgroupwasslighterthantheCAPgroup'smyalgia,numbhandsandfeetinTPgroupwasstrongerthantheCAPgroup'(P<)・Therewasnodifferencesinresponseofstomatitis,alopecia,feverandflushbetweentwogroups(P>0・05)・ConclusionTPisclinicallymoreeffectivethanCAPinfirstlinechemotherapyforthetreatmento