文档介绍：止嗽立效胶囊的毒理学研究作者:王卉,尤春来,穆培,李云兴【关键词】止嗽立效胶囊;,,药理学;,,毒性摘要:目的观察动物ig止嗽立效胶囊的急性毒性和长期毒性。方法ig小鼠作急性毒性实验,观察中毒症状并测定LD50及95%平均可信限。,,・-l・d-l(临床人用量60,120,240倍)ig大鼠连续6周,观察大鼠的生长发育、血液学、血液生化学、脏器指数、组织病理学变化及停药2周后上述指数的变化。结果小鼠igLD50为17・4g・kg-l(胶囊),・kg-l(生药)。长期ig中、高剂量可抑制雄性大鼠体重增长,低、高剂量组雌性大鼠脾脏重量减轻,低剂量组雌性、高剂量组雄性大鼠胸腺重量减轻。对各剂量组大鼠血液学有一定影响。其它指标均无明显异常。结论止嗽立效胶囊具有一定毒性。关键词:止嗽立效胶囊;药理学;毒性ToxicologicStudyonZhisoulixiaoCapsuleAbstract :tivcToobscrvcthcacutctoxicityofZhisoulixiaoCapsulc(ZC)inmiceanditslong-periodtoxicitytorats・(LD50)wascalculated・Threegroupsofrats(inhigh,moderateandlowdosageofZC)wereadministeredwithrepeatedgastricinfusionofZCfor6weeks・Bodyweight,hematologicalandhematobiochemicalparameters,ans(theheart,liver,spleen,lungs,kidneys,adrenals,thymus,brain)wereexaminedin6weeksand2weeksaftercessationofZC・・Thebodyweightofmaleratsincreasedslowlyinhigh-dosageandmoderate-dosagegroups・Thecoefficientofspleendecreasedinlow-dosagefemalegroupandhigh--dosagefemalegroupandhigh-dosagemalegroup・・Keywords :ZhisoulixiaoCapsule;Pharmacology:ZhisoulixiaoCapsule;Toxicity止嗽立效胶囊是在止嗽立效丸基础上改变剂型的新药。它由麻黄、石膏、尊茁子、苦杏仁、甘草、罂粟壳等中药组方。药效学研