文档介绍:浙江大学学报(医学版)JOURNALOFZHEJIANGUNIVERSinrY(MEDICALSCIENCES)-214,217文章来源:.cn/med/2000/0005/】治疗慢性动脉闭塞症的临床评估李鸣沈来根张鸿坤潘松龄摘耍:目的:观察脂微球载体前列腺素E^LipoPGEJ对慢性动脉闭塞症的疗效及不良反应。方法:用LipoPGE,10ug静脉推注治疗慢性动脉闭塞29例,用前列腺素E.(PGE.)粉针剂100Ug静脉滴注治疗20例作对照。结IJpoPGE1组与PG%%%(P>)%%(P<)。结论:LipoPGE】治疗慢性动脉闭塞症用PGE】粉针剂1/10的剂量即能达到同样的疗效,且不良反应显著下降,用药方法简便易行。关键词:前列地尔/治疗应用;动脉闭塞性疾病/药物疗法;微球体中图分类号:R969,R543 文献标识码:A文章编号:1008-9292(2000)05-0213-02LipoProstaglandinEiinTreatmentofChronicArterialObstructionLIMing,SHENLai-gen,ZHANGIlong-kun,etal.(TheFirstAffiliatedHospital,CollegeofMedicalSciences,ZhejiangUniversity,Hangzhou310003,China)eAbstract:Objective::10ugLipoPGEiwasadministatedintravenouslyto29patientswithchronicarterialobstruction,:%%inLipePGEiandPGEigroup(P>).%%inLipoPGEiandPGEigrouprespectively(P<).Conclusion:PGEiand10%LipoPGEicanreachthesameeffecttochronicarterialobstructionandsideeffectdecreasessignificantly,:Alprostadi1/theruse;lusivediseases/drugther;Microspheres前列腺索EMPGEJ、具有强烈的扩张血管和抑制血小板凝集作用。是目前治疗慢性动脉闭塞症的有效药物之一。但PGEi通过肺循环时,大部分被灭活,传统的粉针剂只能采用大剂量持续静脉给药,由于强烈的血管刺激及其他副作用,限制了PGEi的广泛使