HPLC法测定盐酸多奈哌齐口腔崩解片的含量.doc

文档介绍：HPLC法测定盐酸多奈哌齐口腔崩解片的含量HPLC法测定盐酸多奈哌齐口腔崩解片的含量第3O卷第3期青岛科技大学(自然科学版)(NaturalScienceEdition):1672—6987(2009)03—0214—03HPLC法测定盐酸多奈哌齐口腔崩解片的含量张媛媛,李风梅,,苏忠亮(青岛科技大学化工学院,山东青岛266042)摘要:建立了一种测定口腔崩解片中盐酸多奈哌齐含量的高效液相色谱(HPLC)(×250mm×5肚m),流动相V(甲醇):V(水):V(三***乙酸)一75:25:,?min_.,,盐酸多奈哌齐在质量浓度为3,30mg?L内呈良好的线性关系(r::=),高,中,,,,相对标准偏差(RSD),,,相对标准偏差<,专属性好,准确度和精密度高,:高效液相色谱法;盐酸多奈哌齐;口腔崩解片;含量中图分类号:R917文献标识码:AQuantitativeDeterminationofDonepezilHydr0chl0rideOrallyDisintegratingTabletsbyHPLCZHANGYuan?yuan,LIFeng-mei,SUFeng,,(CollegeofChemicalEngineering,QingdaoUniversityofScienceandTechnology,Qingdao266042,China)Abstract:—C18column(×250mm×5um)wasusedwithamobilephaseofmethanol—water—trif1uor0aceticacid(75:25:).?—30mg?L().Theaveragerecoveryforhigh,middle,,,,respectively;,,—testandT_testwerenotremarkableindurabilitytestandRSD<,exclusive,accurate,andreliable