文档介绍：
CBR 和 TSPO 在***抑制神经病理性疼
痛中的作用#
魏绪红*
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(中山大学中山医学院生理学教研室疼痛研究中心,广州 510080)
摘要:研究报道***可抑制大鼠炎性痛,但其机制不明。***有两个受体,中枢型和外
周型苯二氮卓受体(现已改名 TSPO)。中枢型苯二氮卓受体与 GABAA 相偶联,而 TSPO
可促进神经甾体如孕烯醇***的生成,进而调控 GABAA 受体。在本实验中,我们观察了这两
个受体在***抑制神经病理性疼痛中的作用。我们发现,不论 TSPO 激动剂 Ro5-4864 还
是孕烯醇***均对神经病理性疼痛具有较长时间的抑制作用,而且,***的抑制神经病理性
疼痛的作用可被中枢性苯二氮卓受体的拮抗剂***马西尼完全阻断。以上结果提示中枢型苯二
氮卓受体和 TSPO 在***抑制神经病理性疼痛中均起重要作用。
关键词:病理生理学;神经病理性疼痛;***;转位蛋白
中图分类号:
The role of CBR and TSPO in the inhibitory effect of
diazepam on neuropathic pain
WEI Xuhong
(Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun
Yat-Sen University,Guangzhou 510080)
Abstract: Previous studies revealed that diazepam can inhibit the inflammatory pain of rats, but its
mechanisms are still not clear. There are two receptors of diazepam, central benzodiazepine
receptor and peripheral benzodiazepine receptor (which has been renamed TSPO). The central
benzodiazepine receptor was coupled to GABAA, while TSPO could promote the synthesis of pro
gnenolone, which then modulate the function of GABAA. In this study, we observed whether
these two receptors play roles in the inhibitory effect of diazepam on neuropathic pain. We found
that intraperitoneal injection of either TSPO agonist Ro5-4864, or prognenolone could inhibit
neuropathic pain. Further more, we found that the inhibitory