文档介绍：晚期食管癌FP方案时辰化疗近期疗效观察王守华、蒋从飞响水县人民医院肿瘤科江苏盐城224600摘要:目的观察FP方案时辰化疗与常规化疗治疗晚期食管癌的近期疗效和不良反应•方法晚期或接受过手术或放疗而复发食的管癌患者80例,随机分为2组各40例,时辰化疗组5-Fu500mg/m;每日22时至次日10时给药,顺钳(DDP)20mg/m2,第1〜第5天,于当天10:00〜22:00给药,每3〜4周为1个周期。常规化疗组5-Fu和DDP的用量及周期间隔同吋辰化疗组,但吋间安排在正常吋间8:00^15:00,普通滴速。两组病例均同样采用5-IIT3受体拮抗剂+地塞米松止吐。完成2个周期及以上化疗者评价化疗近期疗效及不良反应。随访6〜20个月•结果时辰化疗组共完成198个周期的化疗,,有效率为45%。常规化疗组完成189个周期,%。两组总有效率比较差异有统计学意义(P<)。;时辰化疗;疗效;不良反应CurativeEffectObservationofFPChrono-ChemotherapyonAdvancedEsophagealEarcinomaWANGShouhuaJIANGCongfeiDepartmentofOncology,XiangshuiPeople'sHospital,JiangSuYancheng224600[ABSTRACT]OBJECTIVE:Toobserveshort-termefficacyandadversereactionofFPchrono-:advaneedorreceiveoperationorradiotherapyandrecurrenceinpatientswithesophagealcancerin80cases,wererandomlydividedintotwogroupsof40patientseach,Inthecbrono-chemotherapygroup,5-Fu500mg/m",Civdaily22amto10pmthenextclay,(DDP),20mg/m,dltodoonthesameday,10:00-22:00togivemedicine,every3to4weeksforicycles,-FuandDDPdosageandintervalatthesametimechemotherapygroup,butthetimearrangementinnormaltimeSAM-3PM,-3receptorant-~