文档介绍：川茸嗪对妊娠期肝内胆汁淤积的疗效观察[摘要]目的探讨川茸嗪对妊娠期肝内胆汁淤积症(ICP)的治疗作用。方法将60例TCP患者随机分为对照组和观察组,对照组采用熊去氧胆酸等常规治疗,观察组在常规治疗基础上加用川寻嗪,对照组2例失访,最终纳入统计的为对照组28例,观察组30例,观察两组患者瘙痒和血液生化的改善情况。结果观察组瘙痒和血液生化的改善优于对照组,两组差异有统计学意义(P〈〈)o结论川茗嗪适合于ICP的治疗。[关键词]川苛嗪;妊娠肝内胆汁淤积;熊去氧胆酸;甘胆酸[中图分类号][文献标识码]A[文章编号]1674-4721(2013)06(c)-0079-holestasisofpregnancyZOUShengqunServiceStationforFamilyPlanningofIlechengDistrictinHuaihuaCity,HunanProvince,Huaihua418000,China[Abstract]holestasisofpregnancy(TCP).MethodsSixtypatientswithICPweredividedintocontrolgroupandtrialgroup,,,andultimatelyincludedinthestatisticsforthecontrolgroup28cases,trialgroup30cases・Thenscoresonprurituswererecorded,andALT,AST,TBTL,DBTL,,AST,TBIL,DBIL,CGAweresignificantlygreaterintrialgroupthanthoseincontrolgroup,thedifferencesweresignificant(P<,P〈)・ConclusionLigustrazinecanbeusedforICP・[Keywords]Ligustrazine;holestasisofpregnancy;Ursodeoxycholicacid;Glycocholicacid妊娠期肝内胆汁淤积(holestasisofpregnancy,ICP)是怀孕中后期出现,以瘙痒、血清转氨酶和胆汁酸升高为特征的临床综合征,一般分娩后2〜3周消失。ICP是较为常见的妊娠期合并症,发病率为0・8%〜12%[1],严重威胁胎儿安全。ICP患者可因维生素K的吸收减少致使凝血功能异常,导致产后出血,也可发生糖、脂代谢紊乱。但ICP主要危及胎儿安全,由于胆汁酸可以通过胎盘进入胎儿体内,致胎膜早破、胎儿窘迫、白发性早产或孕期羊水胎粪污染筹,使围生儿发病率和死亡率明显升高⑵。TC卩的治疗主耍采用熊去氧胆酸、S腺苗甲