文档介绍：新福菌素联合卡钳、依托泊昔治疗老年非小细胞肺癌临床疗效观察作者:赵建清邢立强钱海红李桂林(河北北方学院附属第一医院呼吸科,河北张家口075000;河北北方学院实验中心,河北张家口075000)【摘耍】目的:评价国产新福菌素对老年非小细胞肺癌(NSCLC)的疗效和不良反应。方法:选取老年NSCLC病例81例,随机分治疗组43例给予新福菌索6Mg/kg(第1〜4d),卡钳(CBP)300mg/m2(第Id),依托泊昔(VP16)100mg(第1〜4或5d)静脉滴注;对照组38例单纯使用CBP和VP16,剂量和方法同治疗组,21〜28d为一个疗程,2〜3个疗程评价疗效,随访缓解期和生存期。结果:治疗组有效率为5349%,对照组有效率为3158%,差异有显著性(Pv005);中位缓解期分别为6和45个月,屮位生存期分别为9和7个月,一年生存率分别为3953%(17/43)和2632%(10/38)。结论:新福菌素联合CBP、VP16治疗老年NSCLC有较好的临床疗效及应用价值。【关键词】老年;非小细胞肺癌;化疗;新福菌素;卡钳;biningCardPlatinumandVP16inTreatingElderlyNonsmallCellLungCancerZHAOJianqing,XINGLiqiang,QIANHaihong,etalRespiratoryDepartment,TheFirstAffiliatedHospital,HebeiNorthUniversity,Zhangjiakou,075000,Hebei,China;HebeiNorthUniversity,Zhangjiakou,075000,Hebei,China)【ABSTRACT】Objective:ToinvestigatethecurativeeffectsandsideeffectofdomesticdrugSinoactionomycinintreatingelderlynonsmallcelllungcancer(NSCLC).Methods:81caseswithelderlyNSCLCweredividedintotwogroupsrandomly,43casesinthetreatmentgroupwereadministratedwithSinoactionomycin6g/kg(1〜biningcardplatinum(CBP)300mg/m2(1stday),glucoside(VP16)100mg(1〜4or5days)〜28daysweretakenasatreatmentcycleandthecurativeeffectswerestudiedafter2〜:Theeffectivenessfortreatmenttroupis5349%,effectivenessforcontrolgroupis