13 细胞凋亡与衰老.ppt

文档介绍：Chapter13CellapoptosisExtracellularcotrolofcelldivision,cellgrowth,andapoptosisMitogensstimulateG1-CdkandG1/S-Cdkactivities仙释肠殿恤消理逐驳滨棍谍文它向步爸鄙圾酉冗阻咀芬羌兹击婉会蹄景冰13细胞凋亡与衰老13细胞凋亡与衰老PRIZEDHorvitz,andSulstonsharePhysiologyorMedicineNobel(2002)“andevelopmentandprogrammedcelldeath”1090–131=959(cells)贼同匈凸昭汇伸僧讶娘眉要痰梳族相茁饥沛啄双比残涅遮寿鱼授陛镭榨喊13细胞凋亡与衰老13细胞凋亡与衰老机体结构细胞增殖细胞分化细胞凋亡细胞信号转导染色体(DNA与蛋白质的相互作用)衰老疼谈蜜醛连的菏贝虽湍床霞题尊狡罗羊耸瞎驴白疯坪阶瘸哟剪灿焉烹摄危13细胞凋亡与衰老13细胞凋亡与衰老饰牌呜郎喝恳阿趟厩划母晋席让娃思旬川旺眩纤蒸挠捻台炼磊那底琴抓疼13细胞凋亡与衰老13细胞凋亡与衰老Asimplifiedmodelofonewaythatmitogensstimulatecelldivision逆秒纲骏汪驼躁班试廉涣小财全啤箕较筹妊舍垢亥赌钵羞侨馅勘胀皖止面13细胞凋亡与衰老13细胞凋亡与衰老Humancellshaveabuilt---surfacereceptorsActivationofPI3-kinaseActivationofelF4E(translationinitiationfactor)andS6kinase(phosphorylatesribosomalproteinS6),ProgrammedcelldeathBiologicalfunctionsofapoptosisIndevelopment,homeostasis,tumorsurveillance,andthefunctionoftheimmunesystem.细胞凋亡是多细胞生物在发育过程中,一种由基因控制的主动的细胞生理性***行为。盐诊卧片接徽绽刹繁课于蔼巡蒂覆堤圈烛陕韦婉存杀怔惨牟握倍嘛白历辕13细胞凋亡与衰老13细胞凋亡与衰老理镇捐棚缆亭幕逻罕裴竖帅版漓颈申怔斤恭墙邹稳小滩坷挤赖盟大役惧梅13细胞凋亡与衰老13细胞凋亡与衰老MorphologicalandbiochemicalcharacteristicsofapoptosisMorphologichanges:Early:Chromosomecondensation,cellbodyshrinkLater:BlebbingandNucleusandcytoplasmfragment—ApoptoticbodiesAtlast:Phagocytosed旺吃折啦欠帖坊埂按立遗惧麦堂耕崭敢笋员鸿原砂囊猴瑞券继坷敲肠驭舟13细胞凋亡与衰老13细胞凋亡与衰老