盐酸多奈哌齐治疗神经衰弱伴发认知障碍的临床研究.doc

文档介绍：盐酸多奈哌齐治疗神经衰弱伴发认知障碍的临床研究【摘要】-3神经衰弱诊断标准的患者93例,随机分成治疗纽•和对照纽。治疗纽采用盐酸多奈哌齐合并阿米替林,对照组单用阿米替林治疗,12周为一疗程。治疗前及治疗后第4,12周,进行CGI、MMSE、HAMD评定,比较治疗前后两纽的效果。结果治疗结束时,两组CGI均有显著变化;治疗组MMSE评分差异有显著性;、焦虑/妪体化、阻滞、睡眠障碍因子评分差异有显著性,治疗组认识障碍因子评分差异有显著性;治疗纽•与对照组阻滞、睡眠障碍因子评分差异有显著性。结论盐酸多奈哌齐合并阿米替林对神经衰弱疗效明显,特别对记忆、注意力、激越、睡眠质量的改善更明显。【关键词】神经衰弱盐酸多奈哌齐认知障碍ClinicalResearchofDonepezi1HydrochlorideTherapyforCognitiveImpairmentinNeurastheniaCLUPeilin,,SirRunRunShawHospital,Schoolofmedicine,ZhejiangUniversity,Hangzhou,310016,China•)[Absact]—(CGI),MiniMenta1StateExamination(MMSE)andHami1tonRatingSca1eforDepression(HAMD),「eductionofHAMDtotalscore,anxiety/somatizaLion,retardation,,especiallyonmemory,attention,agitationandsleepquality.[Keywords]Neurasthenia,Donepezi1hydrochloride,Cognitiveimpairment神经衰弱(Neurasthenia)是指精神