文档介绍：MedicinalChemistryMedicinalchemistry(药物化学)isadisciplineofchemistrythatconcernsitselfwiththediscovery,:Medicinalchemistryisachemistry-baseddiscipline,involvingaspectsofbiological,,discovery,design,pounds,thestudyoftheirmetabolism,theinterpretationoftheirmodeofactionatthemolecularlevelandtheconstructionofstructure-activityrelationships(SAR),(Left)(phototakenonJuly7,2006).(formerlyUniversityofSunderland,UK),AndySeniorLecturerinMedicinalChemistry(inthemiddle)gave10WelshSchoolofPharmacylecturestotheundergraduateCardiffUniversity,(year2006class)4Keypoints:'sRanitidine(Zantac)雷尼替丁Pfizer'sSildenafil(Viagra)西地那非NH2OHHHHHNONSOONHOOH2NCO2HICI'sAtenolol(Tenormin)阿替洛尔SmithKlineBeecham'sAmoxicillin阿莫西林7西药假药Drug(Medicine)FakeDrugSmallmoleculedrugs(hemicals)毒品BiologicsStreetorclubdrugs(biologicalmacromolecules)保健食品中药(中成药)plementaryMedicine安慰剂AlternativeMedicine]Placebo8ThedefinitionofadrugAdrugmustmeetthe(medicine)hemical,noteffectsandsideeffects().,???‘TheDoseMakesthePoison’‘Wasistdasnitgifftist?alledingsindgift/undnichtsohngifft/Alleindiedosismachtdaseindingkeingiftist.’Whatisnotpoison?Allthingsarepoisonandnothing[is]