文档介绍：四种药物联合检测对2型糖尿病早期肾损伤诊断的探讨作者:叶晓涛,许瑞环,廖长征,何国坚,尹学念【关键词】,微量白蛋白;al[摘耍]目的:探讨尿微量白蛋白(mALB).al微球蛋白(ci酶(NAG)联合检IMG)、B2微球蛋口(B2MG)和N乙酰BD氨基葡萄糖甘测对5年以上病程2型糖尿病(NTDDM)患者肾损伤早期诊断的价值。方法:、02MG和NAG含量。结果:2型糖尿病患者尿MIE、aIMG、B2MG、NA***平均显著高于对照组(P<)oNTDDM患者中,%,4项指标的单项或联合检测的敏感性远远高于常规尿蛋白测定,单项检测的阳性率较低,联合检测阳性率较高,其中aIMG+32MG+%,%O结论:、B2MG和NAG是NIDDM患者早期肾损害的敏感指标,联合检测3项〜4项指标有较高的阳性率,对于2型糖尿病患者早期肾损伤诊断有一定的临床意义。[关键词]微量白蛋白;Q1微球蛋白;B2微球蛋白;N乙酰BD氨基葡萄糖背酶;ephropathiesbyMutipleTumorMarkerswithUrinarymALB>ciIMG、02MGandNAGAbstract:binedurinarymALB>aIMG、02MGandNAGfordiagnosisofearlyrenaldiseasewithmorethan5yearsintype2diabetesmel1itus・Methodsbydetermine80type2diabetesmellituspatientsand60normalpersonsurinarymALB>aIMG、>aIMG、02MGandNAGtype2diabeticgroupwerehigherthanthoseinthecontrol(卩<).%,Positiverateofthethreeitemstogether(aIMG+B2MG+NAG)%%・ConclusionUrinarymALB>aIMG、P2MGandNAGissensitiveandreliablefordiagnosisofearlyrenaldisease,hreeorfourtogetherwerehigherandfordiagnosisofearlyrenaldiseaseintype2diabetesmellitushaveclinicalsignificance・Keywords:Urinarymicroalbumin;almicroglobulin;B2microglobulin;NacetylBDglucosaminidase;Type2diabetesmellitus糖尿病肾病(DN)是糖尿病重要的慢性并发症之一,随着糖尿病的病情加重,其发生DN几乎无可