文档介绍：95%CI(,),p=]、重度血红蛋白下降[RR=,95%CI(, ),p=]、重度恶心、呕吐[RR=,95%CI(,),p<]、肾功能损害[RR=,95%CI(,),p=]发生率低于GP方案,但 GO方案具有较高的周围神经毒性[RR=,95%CI(,),p-], 二者在重度血小板下降[RR=,95%CI(,),p=]、肝功能损害[RR=,95%CI(,),p=]、脱发[RR=,95%Cl(, ),p=]方面无统计学意义。亚组分析提示:Go方案与GP方案在重度肾功损害[RR=,95%CI(,),p=]、重度周围神经毒性[RR=, 95%CI(,),p=]方面不存在统计学差异,在老年患者的化疗后客观反应率[RR=,95%CI(,)]、肿瘤控制率[RR=,95%CI(, )]、重度白细胞下降[RR=,95%CI(,)]、重度血小板下降[RR=,95%CI(,)]方面没有统计学差异。结论;口陌 GO方案治疗晚期非小细胞肺癌疗效确切且相对安全。与传统的一线标准方案相比,GO方案达到了与其相似的客观有效率、肿瘤控制率及1年生存率,并且具有较低的重度白细胞下降、重度血红蛋白下降及相对较轻的消化道反应和肾功损害,但具有较高周围神经炎发生率,多轻微且可逆。可作为晚期非小细胞肺癌治疗的新选择。关键词非小细胞肺癌;奥沙利铂;顺铂;吉西他滨;Meta分析 2 ·英文论著摘要· Curative effectand security ofoxaliplatin plus gemcitabine foradvanced non small celllung cancer:a meta-analysis obj ective Metaanalysis oftheefficacy andsafety oftreating advanced non—small celllung cancer谢tIl bined oxaliplatin(GO)chemotherapy versus bined cisplatin(GP)chemotherapy,is toprovide evidence-based basis for areasonableelinicaltreatment. Methods An electronicsearchiSperformed inPubMed,China biomedicine literature database(CBM),China national knowledge KI)digital library,Chinese scienceandtechnology periodical database(V1P)and Wangfang (including theCJLC)were checked closing date for retrieval was December 3 1吼20 test group Was bined oxaliplatin chemotherapy and control group was bined cisplatin two researchers independently made quality assessmentand dataextraction for theeligible trials,metaanalyzed with ,the publication biasWas double checked州th Egger’S recentobjective response rate,tumor controlrate,toxicity、oneyear survival rate,median survivaltime,the median time to progression,quality oflife, treatment-related deaths as index ofobserving,RR valueofeach instance were calculate