盐酸帕罗西汀治疗脑卒中后抑郁的疗效分析.doc

文档介绍：盐酸帕罗西汀治疗脑卒中后抑郁的疗效分析作者:毛向莹单位:长垣县人民医院神经内科,河南长垣453400【摘要】目的观察盐酸帕罗两汀对脑卒中后抑佃(PSD)的疗效。方法60例PSD患者随机分为治疗组和对照纽,每组30例。对照纽给了脑血管病當规治疗,治疗纽在常规治疗基础上给予盐酸帕罗西汀,每日1次,每次20mg•d-l,晨起口服。2纽疗程均为8周。治疗前、治疗第8周行汉密尔顿抑郁最表(HAMD)评分,并评定其疗效和不良反应。结果治疗纽•痊愈10例,显著进步8例,进步9例,无效3例,有效率90%;对照组显著进步5例,进步7例,无效18例,有效率40%,2组比较有显著性差异(χ2=,P<),且治疗纽不良反应明显少于对照纽(χ2=:,P<)o结论盐酸帕罗西汀能较好地改善脑卒中后的抑郁情绪,是治疗PSD的理想药物之一。【关键词】帕罗西汀脑卒中抑郁EffectofparoxetinehydrochlorideonpatientswithpoststrokedepressionMAOXiangyingDepartmentofNeurology,thePeople′sHospitalofChangyuanCounty,Changyuan453400,ChinaAbstract:ObjectiveTostudythecurativeeffectsofparoxetinehydrochlorideonthetreatmentofpoststrokedepression(PSD).MethodsSixtypatientswithPSDwererandomlydividedintotreatmentgroup(n=30)andcontrogroup(n=30).reatmentforcerebrovasculardisease,andthetreatmentgroupwerereceivedparoxetinehydrochloridetreatment,,theclinicaleffectsandadversereactionwereassessedwiththeHamiltondepressionscale(HAMD).ResultsIntreatmentgroup,tencasewererecovery,eightcasesweresignificantadvancement,ninecaseswereprogressandinefficiencywastwocases,theeffectivepowerwas90%.Incontrolgroup,fivecasewererecovery,significantadvancementwassevenandinefficiencywaseighteencases,theeffectivepowerwas40%.Therewassignificantdifferencebetweenthetreatmentgroup(90%)andthecontro