文档介绍：青岛大学硕士学位论文淋巴瘤病人MMP--2和TIMP--2的表达及其临床意义姓名:许宏申请学位级别:硕士专业:内科学(血液病)指导教师:赵洪国淋巴瘤病人MMP-2和Tl_P-2的表达及其临床意义摘要目的探讨淋巴瘤病人血清基质金属蛋白酶-2(MMP一2)和组织金属蛋白酶抑制因子一2(TIMP一2)的表达及其临床意义。结果 淋巴瘤病人血清M船一2、TIMP-2水平及M/T(删P-2/TIMP-2)值均明显高于正常对照组(P<)。NHL病人血清MMP-2水平及M/T值与其病理类型、临床分期和骨髓侵犯等显著相关(P<),血清MMP一2水平越高,M/T值越大,其预后越差。获得缓解的NHL病人血清删P一2水平和M/T比值较初治、复发、难治病人均明显降低,差异具有统计学意义(户<),TIMP-2水平无明显差别(P>);初治、复发、难治NHL病人的血清删P一2水平、TIMP一2水平和M/T}=L值均无明显差别(P>)。HL病人血清删P-2水平及U/T值仅与其病理类型有关(P<),血清MMP-2水平越高,M/T值越大,其预后反而越好。淋巴瘤病人血清删P一2、TIMP-2水平与其血清乳酸脱氢酶(LDH)水平有关,姗P_2水平和TIMP-2水平显著相关。结论 淋巴瘤病人血清MMP一2、TIMP一2水平及比值(M/T)明显升高,检测血清MMP一2、TIMP-2水平及比值(M/T)对淋巴瘤的治疗和预后判断有重要意义。关键词: 淋巴瘤;基质金属蛋白酶一2;组织金属蛋白酶抑制因子一2ClinicalsignificanceofthechangeofserumMMP一2andTIMP-2levelsinpatientswithlymphomaAbstractObjectiveTostudytheserumlevelandrelationshipofMMP·-2andTIMP·-2inpatients、Ⅳ ContentsofserumMMP-2‘andTINIP-2in32patientswithnon-Hodgldn’Slymphomaand8patientswithHodgkin’Slymphomaweredeterminedbyusingenzymelinkedimmunosorbentassay(ELISA),M/T(MMP·2/TIMP一2)ratioWascounted,and10newlydiagnosedpatientswimnon—Hodgkin’slymphomawel"-2andTIMP-2andM/T(MMP一2/TIMP-2)ratioinlymphomapatientswel"paredwithnormalcontrol(P<).ThereWaspositivestatisticalcorrelationbetweenthelevelofSeI'BmMMP一2andM/Tratioandthepathologicaltype,clinicalstage,andbonemarrowinfiltrationinnon-Hodgkin’Slymphomapatiems,thehigherlevelofMMP-2andM/Tratio,-2andM/pleteremission(CR)subjectsofnon-Hodgkin’Slymphomapatientsweresignificantlylowerthanthatinuntreatedandrelapsed/refractorypatients(P<),butnotdifferenttoTIMP一2(P>).TherewerenodifferenceinMMP一2andTIMP一2andM/Tratiobetweenpatientsnewlydiagnosedandrelapsed/,thelevelofserumMMP一2andM/-2andM/Tratio,-2WascloselycorrelatedwimthecontentsofserumLDH,andSOWaSbetweenMMP-2