文档介绍：成都中医药大学硕士学位论文中文摘要目的:以安慰剂为对照评价银杏叶胶囊对眼压控制青光眼患者视野平均缺损指数的影响,分析视野平均缺损指数与视觉电生理P-VEP的关系,并探讨其视功能保护的作用机制。方法:以成都中医药大学附属医院等全国5家医院眼科诊断为青光眼患者为主要研究对象,采用多中心随机双盲平行安慰剂对照的临床研究方法。纳入符合原发性开角型青光眼及急性闭角型青光眼术后诊断标准,且有视野缺损,通过药物或手术控制(术后三个月以上),眼压、<21mmHg,中心矫正视力>/。将其随机分为试验组和对照组,试验组口服银杏叶胶囊,对照组口服安慰剂胶囊,疗程24周。观察治疗前后青光眼有效性指标视野和视觉电生理,评价银杏叶胶囊对眼压控制青光眼视野平均缺损指数的影响。。结果: ,银杏叶胶囊组142例,安慰剂组143例。两组治疗前在视力、性别、年龄、病程、视野缺损程度及视野(MD)等方面的基线资料比较,差异均无统计学意义(P>)。患者试验期间依从性好,无违反试验方案的合并用药和合并治疗方法。 +;:。治疗前后比较,对照组组内差异无统计学意义,试验组组内差异有统计学意义。两组间治疗前后MD差值比较有统计学意义。:i:;,两组间治疗前后MS差值的差异无统计学意义。壁堡耋匿垫奎兰堡圭耋堡墼塞 —、P-VEPlcpdN75 波及P-VEP2cpdNl45波振幅较治疗前明显提高,差异具有统计学意义,对照组治疗前后差异无统计学意义。结论:。 。 。其机制可能是通过压抑钙离子内流,进而抑制细胞的凋亡实现的。关键词: 青光眼:银杏叶胶囊:视野:图形视觉诱发电位;机制 Objecfive: Abstract To evaluate theeffectofGinkgo leafcapsules inmean defects index invisual a patients with controlled intraocular pressure byplacebo-controlled; toanalyze therelationship between mean defectindex invisual fieldand the visual electrophysiology P-VEP,and explore theprotective mechanism visualfunction. Method: Arandomized。,parallel placebo—controlled,multi—center clinicaltrial was a was themainobject were collected attheOphthalmology department of the Affiliated Hospital ofChengdu UIliversity nationwide withthecorrected visual who were diagnosed primary open-angle a and acute angle—closure a aftersurgery with intraocular pressure controlled by medicines or surgery (after more thanthreemonths,intraocular pressure≤21mmHg)and visualfielddefect, were enrolledandrandomly divided into testgroup and testgroup was treatedwithGinkgo leafcapsule,the control group was treated with placebo theco