文档介绍：外文翻译 van Hemert et al. BMC Microbiology 2010, 10 :293 范赫伯特 et al。 BMC 微生物学 1-2180/10/293 RESEARCH ARTICLE ( 研究论文)( 开放存取; 开架阅览 Open Access ) Identification of Lactobacillus plantarum genes ( 鉴定乳酸菌乳杆菌基因) modulating the cytokine response of human ( 调节细胞因子反应的人类) peripheral blood mononuclear cells (外周血单个核细胞)。 Saskia van Hemert 1,2 , Marjolein Meijerink 1,3 , Douwe Molenaar 1,2,4 , Peter A Bron 1,2,5 , Paul de Vos 1,6 , Michiel Kleerebezem 1,2,7 , Jerry M Wells 1,3 , Maria L Marco 1,2,8* Abstract 摘要 Background: Modulation of the immune system is one of the most plausible mechanisms underlying the beneficial effects of probiotic bacteria on human health. ( 背景: 调制的免疫系统是一种最合理的底层机制的有利影响益生菌对人体健康。) Presently, the specific probiotic cell products responsible for immunomodulation are largely unknown. ( 目前, 特定的益生菌细胞产品负责免疫调节主要是未知的。) In this study, the ic and phenotypic diversity of strains of the Lactobacillus plantarum species were investigated to identify genes of L. ( 在这项研究中, 遗传和表型多样性的乳酸菌菌株 plantarum 物种进行调查来确定基因的 L。) plantarum with the potential to influence the amounts of cytokines interleukin 10 (IL-10) and IL-12 and the ratio of IL-10/IL-12 produced by peripheral blood mononuclear cells (PBMCs). ( 乳杆菌与可能影响大量的细胞因子白细胞介素 10(il - 10) 和 il 12和 il- 10 的比例/ il 12 外周血单核细胞产生的(PBMCs) 。) Results: ( 结果:)A total of 42 Lactobacillus plantarum strains isolated from diverse environmental and human sources were evaluated for their capacity to stimulate cytokine production in PBMCs. ( 共有 42 乳酸菌菌株 plantarum 孤立从不同的环境和人力资源进行评估, 等待他们的能力去刺激细胞因子在 PBMCs 生产。) The L. plantarum strains induced the secretion of the anti-inflammatory cytokine IL-10 over an average 14-fold range and secretion of the proinflammatory cytokine IL-12 over an average 16-fold range. ( 植物乳杆菌菌株的诱导抗炎细胞因子的分泌 il- 10 在平均 14 倍范围和分泌的促炎细胞因子 il 12 在平均 16 倍范围。) Comparisons of the strain-specific cytokine responses of PBMCs parative genome hybridization profiles obtained with L. plantarum WCFS1 DNA microarrays (also termed gene-trait matchi