胆管癌最新化疗方案.doc

文档介绍：胆管癌最新化疗方案Background:Thereisnoknowneffectivechemotherapyregimenforpatientswithunresectable/,binationofirinotecan,capecitabine,:From9/03to11/04,8chemotherapynaivepatientswithatissuediagnosisofunresectable/cholangiocarcinomawereseenandtreatedwitharegimenconsistingofirinotecan120mg/m2onDI,capecitabine1500mg/m2Dl-14andcelecoxib200mgbiddaily,:Sixfemalesandtwomales,age56-63(medianage=60)zperformancestatus(PS)between0---6068u/ml(normal<33).7patientsevaluableforCA19--9wasseenin100%(5/7>80%decline).CTscan:2/7hadstablediseaseand2/7hadaminimumresponse(<20%decreaseintargettumorsize).Toxicity:diarrhea:5/7grade0,2/7grade1;hand-footsyndrome:6/7grade0,1/7grade1;anemia:1/7grade0,4/7grade1,2/7grade2;neutropenia:4/7grade0,1/7grade1,2/-(1-15monthsfrominitiationoftreatment).:XICiswelltoleratedinpatientswithunresectable/-escala