文档介绍：Lecture7 HighPressureLiquidChromatography HPLCLecture7–HPLC,23-10-*©,GUCObjectivesDefineHighPerformanceLiquidChromatography(HPLC).Describeindetailtheset-–HPLC,23-10-2012©,GUC*RealisticSet-UpofyourHPLC (location:instrumentalanalysislaboratory,B7-303)©,GUC*Lecture7–HPLC,23-10-?HPLCisonemodeofchromatography,,,://studyhplc/,HPLCacquiresahighdegreeofversatilitynotfoundinotherchromatographicsystemsandithastheabilitytoeasilyseparateawidevarietyofchemicalmixtures.©,GUC*Lecture7–HPLC,23-10-2012HPLCinpharmaceuticalanalysis fromdrugdiscoverytoqualitycontrolHPLCisthedominanttechniqueforpharmaceuticalanalysisusedinresearch,development,andqualitycontrolwiththefollowingfunctions:Drugdiscovery:findingnewchemicalentities(NCE):developingviablesyntheticroutesandscale-upprocessesforsynthesizingactivepharmaceuticalIngredients(API).Pharmaceuticaldevelopment:(DMPK):(QC):assessingthequalityofthefinalmanufacturedproductsagainstpublishedspecificationforproductrelease.©,GUCLecture7–HPLC,23-10-2012*().Smalldiameter()stainlesssteel,(3,5and10μm)