文档介绍：盐酸昂丹司琼口腔崩解片的处方优化余前四川大学牛物制药国家重点实验室(四川成都610000)【摘要】木品为口腔崩解片制剂,活性成份盐酸昂丹司琼,对因放疗、化疗及手术引起的恶心和呕吐具有良好的预防和治疗作用。在肿瘤放疗、化疗治疗过程中,肿瘤病人吞服普通片存在一定困难,口腔崩解片无需饮水即可在唾液中迅速崩解,进而释放药物,在口腔内即开始吸收,使病人顺利服药。制备口腔崩解片的关键在于寻找合适的辅料,以确保压片时流动性好、可压性强、在一定硬度下崩解快,此外还要求所制得的片剂口感要好。通过实验优选最佳处方,工艺采用湿法制粒。处方筛选中,以工艺过程的难易程度、颗粒成型性、片面光洁度、崩解时限、口感等为考察指标进行筛选。【关键词】口腔崩解片 湿法制粒处方筛选[中图分类号]R943 [文献标识码]A [文章编号]1810-5734(2013)10-90-05OndansetronhydrochlorideorallydisintegratingtabletformulationoptimizationYuQian(SichuanUniversity,StateKeyLaboratoryofPharmaceuticalBiotechnology,Chengdu,Sichuan610000)[Abstract]Thisproductisorallydisintegratingtabletformulation,theactiveingredientofondansetronhydrochloride,duetoradiotherapy,chemotherapyandsurgery-,chemotherapytreatment,cancerpatientstherearecertaindifficultiesswallowingconventionaltablets,orallydisintegratingtabletswithoutwatercanberapidlydisintegratinginsaliva,therebyreleasingthedrugintheoralcavitythatbegantoabsorb,,fastdisintegratinginacertainhardness,!onthroughexperiments,,thedegreeofdifficultyintheprocess,particlesformability,one-sidedfinish,disintegration,taste,.【Keywords]OraldisintegratingtabletsWetgranulationPrescriptionscr