文档介绍：晚期肺腺癌患者一线化疗后吉非替尼维持治疗临床观察[摘要]目的评价晚期肺腺癌患者一线予含钳两药联合化疗后予吉非替尼维持治疗的有效性及安全性。方法收集我院2007年8月-2009年2月23例经病理组织学和(或)细胞学检查确诊的晚期肺腺癌患者,男7例,女16例,中位年龄63岁(39岁-73岁),均行含钳的三代药物(如紫杉醇,多西紫杉醇,培美曲赛,长春瑞滨)两药联合方案化疗2~4周期,疗效评价为部分缓解(PR)及稳定(SD)后,予吉非替尼维持治疗,吉非替尼250mg每日一次,持续服药至疾病进展或出现不可耐受得毒副反应。结果除1例患者服药1个月后因经济原因自行停药,余22例患者均可评价疗效,其中完全缓解(CR)1例,部分缓解(PR)7例,稳定(SD)10例,进展(PD)4例,%,%,中位中位无疾病进展生存期约为9个月,%,不良反应主要为皮疹及腹泻,对症治疗后均可耐受。结论予晚期肺腺癌患者一线予含钳两药联合化疗后予吉非替尼维持治疗获得了较好疗效,且不良反应轻,耐受性好。[关键词]吉非替尼;肺腺癌;维持治疗[中图分类号]:文献标识码]A[文章编号]1005-0515(2011)-04-022-02ClinicalObservationofContinuousMaintenanceTherapy(CMT)withGefitinibAfterFirsineChemotherapyofLungAdenocarcinomaLijundongXushuliRenxiaoan("sHospital,Dalain116021,P・RChina)[Abstract]ObjectiveToevaluatetheeffectsandsecurityofContinuousMaintenanceTherapy(CMT)withGefitinibafterfirstTinechemotherapyofLungAdenocarcinoma・MethodsTotally23patientswereenrolledwithadenocarcinomaoflungdiagnosedbypatholoClinicalObservationofContinuousMaintenanceTherapy(CMT),16werewomen,themedianagewas63years(from39to73years)・binedregionwiththird-generationplatinumatleast2cycles,aftertheevaluationofPRorSD,receivedCMTwithGefitinibatthedoseof250mg/m2/daytillPDorcouldn?,22werecurative,1gotCR,7werePR,10wereSDand4gotPD,theoverallresponserate(CR+PR)%,theclinicalbenefitrate(CR+PR+