分子生物学（杨洋）第七章 翻译.ppt

文档介绍：Topic 8
Antibiotics (抗生素）and translation
Date
1
编辑版ppt
Antibiotics inhibit cell division by blocking specific steps in translation—a powerful tool to fight disease
Targets of many antibiotics are translational machinery
Date
2
编辑版ppt
Overview of the events of translation
Termination
Elongation
Initiation
Date
3
编辑版ppt
链霉素
***霉素
四环素
红霉素
Date
4
编辑版ppt
Molecular target: peptidyl transferase reaction
center of 50S subunit
Inhibit peptidyl transferase reaction specifically
***霉素
Date
5
编辑版ppt
四环素
Molecular target: A site of 30S subunit
Inhibit aminoacylated-tRNA binding to A site
Date
6
编辑版ppt
In addition to medical benefits, antibiotics can play important role in research for understanding the function of translational machinery
Date
7
编辑版ppt
Puromycin (嘌呤霉素)
Puromycin resembles the aminoacylated-tRNA,
so it can bind to the A site of ribosome
Date
8
编辑版ppt
Date
9
编辑版ppt
Puromycin (嘌呤霉素)
肽酰嘌呤霉素
(peptidyl-puromycin)
Puromycin
Date
10
编辑版ppt