文档介绍：免疫耐受与免疫排斥
妊娠对于母体而言，是一种半同种异体移植物
•移植是否成功——免受母体免疫系统攻击，涉及母胎面的
免疫耐受与免疫排斥
母一胎界面免疫活性
71
母一胎界面中的子宫蛻膜局部：聚集多种免疫活性细胞, 产生不同细胞因子，发挥不同作用 • Thl:参与细胞介导免疫及巨噬细胞活化、NK细胞激活 • Th2:介导体液免疫反应
Thl/Th2
• Thl:TNF-a
IFN-y
IL-2
IL-12
• Th2:IL-4
IL-5
IL-6
IL-10
IL-13
成功妊娠的维持
• Thl型细胞因子：抑制胚胎着床、滋养细胞生长，导致
流产****惯性流产的发生 • Th2型细胞因子：抑制Thl型细胞因子介导的免疫应答 •正常妊娠：母体免疫系统主要的细胞因子是Th2型细
胞因子，从Thl向Th2方向转化
Raghupathy R. Seminars in Immunology 2001; 13: 219-227.<br****惯性流产<br****惯性流产(habitual abortion , HA )：连续自然流 产3次或3次以上
•生育期妇女中****惯性流产发生率约占1%~5%<br****惯性流产的病因
•已知病因(50-60%)
•未知病因(40-50%)
•缺乏免疫抑制
•母亲Th1细胞因子T
-母亲Th2细胞因子丄
Raghupathy R. Seminars in Immunology 2001; 13: 219-227.
母-胎界面中免疫排斥
CopymZ 0 /W9
AJK! “ ‘ 22
PtutlCti iff h chut J ・ m〃 <• u rrt •/
Araertcjn |ournil o( Reproductive Immuoolcqg
IS£N 8755^920
Why Did Your Mother Reject You?
Immunogenetic Determinants of the Response to Environmental Selective Pressure Expressed at the Uterine Level
David A. Ci ark, P?£Tra C Auck. and Glrard Chaouar
"Why did your motlier reject you?” one asks, while peering down a microscope tube at the remnants of a spontaneously aborted embryo. There are many proposals as to why she did not? if she did not; but until we know why she rejected you and how，we will never know the answer.