文档介绍：1
第15章 肝功能不全
Hepatic insufficiency
主讲：孙晓东
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Metabolism (synthesis
& catabolism)
Secretion and Excretion
Detoxication
Immune function
Coagulation-anticoagulation
……
Normal function of liver
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jaundice
bleeding
infection
renal dysfunction
encephalopathy
Severe damage in liver cells
Causes
Dysfunction of：
excretion,
synthesis,
detoxification,
metabolic and
immune functions
……
Hepatic insufficiency
基本概念（Concept ）
Manifesting as:
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Hepatic failure is a terminal stage of hepatic insufficiency.
Its primary clinical manifestations are hepatic encephalopathy and hepatorenal syndrome.
基本概念（Concept ）
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§1 概 述
肝脏疾病的常见原因和机制
肝脏细胞与肝功能不全
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一、肝脏疾病的常见病因和机制（Causes of Liver Disease）
Biological factors
肝炎病毒 ;
寄生虫；
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一、肝脏疾病的常见病因和机制（Causes of Liver Disease）
Biological factors
Physical and chemical
Some drugs, alcohol, toxins etc.
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一、肝脏疾病的常见病因和机制（Causes of Liver Disease）
Biological factors
Physical and chemical
Genetic Factors
Wilson disease
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一、肝脏疾病的常见病因和机制（Causes of Liver Disease）
Biological factors
Physical and chemical
Genetic Factors
Immunity Factors
Abnormal immune response
Nutritional causes
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二、肝脏细胞与肝功能不全
Hepatocytes
Non parenchyma cells
parenchyma cell
Kupffer cells
Hepatic satellite cells
Liver-associated lymphocytes(LAL)
Hepatic sinusoid endothelial cells