文档介绍：本科毕业论文学生姓名: 学号: 院系: 专业: 化学(化学制药与现代分析技术) 写作时间: 2012 — 2013 学年第一学期毕业论文题目: 阿司匹林的合成及其表征指导教师姓名: 论文完成日期: 2012 年 10月 30日导师评语: 成绩教研室主任系主任本科毕业论文中文摘要 I 南京大学本科生毕业论文中文摘要首页用纸毕业论文题目: 阿司匹林的合成及其表征化学(化学制药与现代分析技术) 专业 2010 级专升本学生姓名: 指导教师(姓名、职称):摘要阿司匹林诞生于189 9年3月6日,是一种历史悠久的解热镇痛药。早在185 3 年夏尔· 弗雷德里克热拉尔( Gerhardt ) 就用水杨酸与醋酐通过酰化反应合成了乙酰水杨酸,但没能引起人们的重视; 1898 年德国化学家菲霍夫曼又进行了合成,并为他父亲治疗风湿关节炎,疗效极好; 1899 年由德莱塞介绍到临床,并取名为阿司匹林(Aspirin) 。到目前为止,阿司匹林已应用百年,成为医药史上三大经典药物之一,可用于治感冒、发热、压痛、头痛、关节痛、风湿,还能抑制血小板聚集,用于预防和治疗缺血性心脏病、心绞痛心肺梗塞脑血栓形成等疾病。本实验以浓硫酸为介质,通过水杨酸和乙酸酐发生乙酰化反应生成乙酰水杨酸,然后通过红外光谱和荧光光度分析法对合成的产品分别进行鉴定和含量测定。[ 关键词] 阿司匹林红外光谱酰化反应荧光光度法本科毕业论文中文摘要 II 关键词: 本科毕业论文英文摘要 II 南京大学本科生毕业论文英文摘要首页用纸 THESIS: Synthesis and characterization of aspirin SPECIALIZATION: Chemistry POSTGRADUATE: Changjun Hou MENTOR: Abstract Aspirin was born in March 6th, 1899,which has a long history for the use of antipyretic analgesics . Early in1853, Charles Frederic Gerard ( Gerhardt ) has synthesized acetylsalicylic acid with salicylic acid and acetic ,it hasn ’t caused people ’s attention ; In1898,a chemist Fehoffman in German did this experience ’s more, this time he has applied it in the treatment of his father ’s rheumatoid his surprise,the treatment has a great ess; Then in 1899,this pound known as aspirin ( Aspirin )was introduced to clinical by Dreiser. So far, aspirin has been used for hundreds of years,and it has e one of the three big classical drug in the chemical can be used to treat cold, fever, tenderness, headache, joint pain, rheumatism, and inhibit platelet aggregation, it also has great effect on the prevention and treatment of ischemic heart disease, angina pectoris pulmonary infarction cerebral thrombosis and other diseases. We has carried out the experience with the salicylic acid and acetic anhydride acetylation,also the reaction occurrence of acetylsalicylic acid was in the medium of concentrated sulfuric spectroscopy and fluorescence analysis method were