文档介绍：Uterine Cancer
Xi-Shi Liu
Obstetrics and Gynecology Hospital
Fudan university
General Description
Also called endometrial cancer
Endometrial cancer is one of the mon malignancy of female genital tract.
General Description
A malignant epithelial disease that occurs in endometrial gland of uterus
The incidence of endometrial cancer is increasing worldwide in recent years.
Risk Factors
1. Medical conditions
a. Diabetes mellitus, hypertension.
b. Overweight---obesity (excess estrogen as a result of peripheral conversion of adrenally derived androstenedione by aromatization in fat).
c. Late menopause.
Risk Factors
2. Some gynecologic diseases
( Long-term endogenous estrogen exposure )
- polycystic ovary syndrome
- functioning ovarian tumors
- anovulating dysfunctional bleeding
- Infertility, Nulliparity.
Risk Factors
3. Prolonged Use of estrogen
a. Prolonged menopausal estrogen replacement therapy without progestogen.
b. Prolonged use of the antiestrogen tamoxifen for breast cancer.
Risk Factors
4. ic factors and other factors
a. Endometrial and ovarian cancer are the simultaneously occurring with other genital malignancy ,reported incidence (~%).
b. Family history of tumor is higher.(12-28%)
Classification
Estrogen dependent and estrogen
independent are two different ic types:
-- One with history of exposure to unopposed estrogen (either endogenous or exogenous).
-- Other type with no source of estrogen stimulation of endometrium.
Five histological subtypes
Endometrioid adenocarcinoma
Mucinous carcinoma
Serous adenocarcinoma
Clear cell carcinoma
Other rare subtypes
Five histological subtypes --Endometrioid Adenocarcinoma
Account for about 80~90%.
Well differentiated.
Prognosis is better.