於强－血管炎病的诊断与治疗.ppt

文档介绍：Vasculitides  Fudan university Zhongshan Hospital Yuqiang
The term vasculitis refers to a heterogeneous group of  disorders characterized  pathologically by evidence of  blood vessel inflammation and  clinically by a diverse set of  symptoms and signs.
Pathology three types: 1. necrotize 2. granulomas 3. only inflammatory cellular  infiltration in the vessel wall
Cause to wall angusty, blunting、 fibrosis, aneurysm  2. tissue ischemia,  functional impaiement
CLASSIFICATION  1. histopathologic  (1)necrotize (2)granulomas (3)leucocytoclasia  (4)giant cell
2. clinical classific infectivity  un-infectivity
3. clinical+ histopathologic primarily skin systemic secondary
Lie CLASSIFICATION primarily large-vessel  Takayasu artertis giant cell artertis Medium-vessel polyarteritis nodosa  Churg-Struss syndrom  Wegener’s granulomatosis small-vessel  Microscopic polyangiitis  Schonlein-Henoch syndrom
Secondary infectivity drug connective tissue disease associated with tumer
pathogenesis  1. infectivity 2. plex  3. antineutrophil cytoplasmic antibody  ANCA-PR3 ANCA-MPO attack vessel AECA  GBM antibody immune