文档介绍：Chapter 28 Osteoporosis
Presentation: 2005
谢瑞满 Rui-man Xie,., .
Professor of Neurology & Gerontology
ZhongShan Hospital, Fudan University
rmxie@, xieruiman@
Objective
1、Definition、types and mechanism of osteoporosis2、 Diagnosis、prevention and treatment of osteoporosis 3 、Etiology and Epidemiology of osteoporosis
times – 45 minutes×2
Overview
Definition : Osteoporosis is a bone disease in which the amount of bone is decreased and the structural integrity of trabecular bone is impaired. Cortical bone es more porous and thinner. This makes the bone weaker and more likely to fracture.
figures
Associated changes in body shape and vertebra (deleted 6 pictures)
normal
50yrs
above 55yrs
above 75yrs
kyphosis
Patients with risk factors or conditions that cause osteoporosis
Postmenopausal woman with family history of hip fractures or kyphosis
Medications: corticosteroids, dilantin, gonadotropin releasing hormone agonists, loop diuretics, methotrexate, thyroid, heparin, cyclosporin, depot-medroxyprogesterone acetate
Hereditary skeletal diseases: osteogenesis imperfecta, rickets, hypophosphatasia
Endocrine and metabolic: hypogonadism, hyperparathyroidism, hyperthyroidism, Cushing syndrome, acidosis, Gaucher's disease
Marrow diseases: myeloma, mastocytosis, thalassemia
Others: Anorexia, Malabsorption, Cystic fibrosis, Renal insufficiency, Hypercalciuria, Hepatic disease, Depression, Spinal cord injury, Systemic Lupus, Weight below healthy range, Cigarette smoking
Epidemiology
The population of older men and women has been increasing, and therefore the number of people with osteoporosis is increasing.
In the USA, about 21% of postmenopausal women have osteoporosis (low bone density), and about 16% have had a fracture. In women older than 80, about 40% have experienced a fracture of the hip, vertebra, arm, or pelvis.
Women have more osteoporotic fractures than men. Age is one of the most important risks in all groups.
The decreased physical a